广东威尔医院,wellclinic,威尔医院骨科
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门诊时间(无假日医院)
早上8:00 - 晚上21:00

紧急联系电话:020-38063333

陈金娜

研究方向: 细胞生物学, 肿瘤遗传学

学习工作经历
博士后(Postdoctoral fellow) 解剖与细胞病理学系Department of Anatomical and Cellular Pathology, 香港中文大学The Chinese University of Hong Kong, 香港Hong Kong, Year 2015-2017年
博士PhD.  临床肿瘤学系Department of Clinical Oncology, 香港大学The University of Hong Kong, 香港Hong Kong, Year2011-2015年,
硕士M.S. 分子医学Department of Cancer Research, 中山大学肿瘤防治中心Sun Yat-Sen University Cancer Center, 广州Guangzhou, 中国China, Year2008- 2011年
理学学士B.S.  生物技术School of Biotechnology, 华南理工大学South China University of Technology, 广州Guangzhou, 中国China, Year2004- 2008年

研究课题与实验技术
  1. 乙肝病毒及非酒精性脂肪肝相关肝细胞肝癌基因组和转录组生物信息学整合分析(主要参与者)。 Integrative analysis ofwhole genome andtranscriptome sequencing in hepatitis B virus (HBV) and Non-alcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC). (Sub-project performer, Paper in preparation)
  2. 转移性鼻咽癌新药物靶点的转录组数据挖据和功能研究(课题设计与执行)。Transcriptome analysisand functional study of drugable targetsfor the treatment of metastatic nasopharyngeal carcinoma (NPC). (Project designer and performer, paper in preparation)
  3. 鼻咽癌早期诊断血清学miRNA生物分子标记物的筛选(主要执行者)。Screening of Epstein-Barr virus (EBV)miRNAs as serology markers for NPC early diagnosis. (Major performer,paper in preparation)
  4. 发现细胞分裂中期调控内质网和高尔基体协同细胞分裂的分子开关(分子开关的发现和关键机制探索)。Discovery of a novel molecular switch regulating endoplasmic reticulum(ER)and Golgi apparatus division during mitosis.(Molecule switch discovery and essential mechanism exploration, paper in preparation)
  5. DNA原位杂交遗传诊断Genetic diagnosis by DNA FISH: 设计并合成DNA探针Design and generate DNA probes; 检测血液细胞及活检组织样品中的基因扩增,缺失,融合,断裂以及基因转位Detection of gene amplification, deletion; gene fusion, breakdown and translocation in blood or tissue samples; 检测基因突变Sequencing forthe detection of gene mutation.
  6. 分子生物学技术,不限于以下所述Techniques of molecular biology include but not limited to: 基因工程gene engineering;实时荧光定量PCR Quantitative Real-time PCR;蛋白质相互作用组学protein interactome; 质谱Mass spectrum; 共聚焦显微技术Confocal microscopic; 流式细胞术Flow cytometry, 荧光标记活细胞成像live cell imaging, 荧光素酶,荧光蛋白标记肿瘤细胞追踪和PET-CT活体动物成像live animal imaging for tumor tracing by luciferase, fluorescence and animal PET-CT.
已发表文献
  1. Chen JN, Xia WX, JiangC,Yu YH, Yang J, LiL, Zhang LF, Ma CQ, Ke LR, Xiang YQGuo X andGuanXY.EGFL6, a potential novel ligand of EGFR, play roles in cancer metastasis by inducing cancer cell Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma. (In preparation)
  2. Alissa Michelle Wong, Jinna Chen, Stephanie Ma ,Aikha Melissa Wong , SaiWahTsao , Jiang-Chao Li , Yan Li , Dora L. Kwong , Janice Wing-Hang Tsang and Xin-Yuan Guan. Epstein-Barr Virus Encoded microRNAs Promotethe Development of Nasopharyngeal Carcinoma by Extensively Activating Wnt Signaling. (In preparation)
  3. Yang J*, Lv X*, Chen J*, Xie C, Xia WX, Jiang C, Zeng TT, Ye YF, Ke LR, Yu YH, Hu L, Guan XY, Guo X and Xiang YQ. CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway.Oncotarget.2016 Mar 29;7(13):15632-47. doi: 10.18632/oncotarget.6695.(* These authors contribute equate to this article).
  4. Li J, Chen JN, Zeng TT, He F, Chen SP, Ma S, Bi J, Zhu XF, Guan XY.CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy.BMC Cancer. 2016 Jan 13;16:15. doi: 10.1186/s12885-016-2050-6.
  5. Xu L, Li X, Cai M, Chen J, Li X, Wu WK, Kang W, Tong J, To KF, Guan XY, Sung JJ, Chan FK, Yu J. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer.Gut. 2015 May 6. pii: gutjnl-2014-308257. doi: 10.1136/gutjnl-2014-308257.
  6. Liu L, Dai Y, Chen J, Zeng T, Li Y, Chen L, Zhu YH, Li J, Li Y, Ma S, Xie D, Yuan YF, Guan XY.Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way ofAkt/GSK-3β/Snail signalling. Hepatology. 2014 Feb;59(2):531-43. doi: 10.1002
  7. Tong M, Chan KW, Bao JY, Wong KY, Chen JN, Kwan PS, Tang KH, Fu L, Qin YR, Lok S, Guan XY, Ma S.Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res. 2012 Nov 15;72(22):6024-35. doi: 10.1158
  8. 7. Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, Zhu Y, Chen S, Xu J, Yan M, Wang J, Liu Q.Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy. 2012 Dec;8(12):1798-810. doi: 10.4161
 
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