广东威尔医院,wellclinic,威尔医院骨科
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王国慧  M.D., 博士 
 
休斯顿麦迪康医学咨询公司 创始人,CEO

联合医生集团顾问医生

学习经历
2013. 4-2015. 8         Baylor College of Medcicine 博士后
2004.9-2007.6          中山大学肿瘤学博士
1998.9-2001.7          中山医科大学研究生核医学专业
1991.9-1996.7          河南医科大学临床医学系

工作情况
2013-5-至今               河南省肿瘤医院兼职副主任医师
2013. 4-2015. 8         Baylor College of Medcicine 博士后
2013. 4-2015. 8         Houston Methodist 研究所博士后
2011.1-2013.5           中山大学肿瘤防治中心影像与介入中心医师
2008.8-2011.1           美国韦恩州立大学医学院博士后
2008.3-2008.7           中山大学肿瘤防治中心影像与介入中心主治医师
2005.7-2006.7           澳大利亚墨尔本Peter MacCallum Cancer Centre ,PET/CT中心进修学习PET/CT技术及分子影像学
2001.7-2005.7           中山大学肿瘤防治中心核医学科主治医师

承担科研课题
1. 肿瘤防治中心单病种课题:PET/CT在鼻咽癌中的应用研究
2. 2004年国家自然基金:TK自杀基因用于鼻咽癌靶向治疗与基因显像的实验研究
3. 2011年 肿瘤医院回国资助:ERLIN2一个新的乳腺癌癌基因功能研究及靶向治疗的实验研究
4.  2013年国家自然基金: ERLIN2 促进乳腺癌细胞生长及调控Herceptin 耐药性的分子机制研究, 70万
 
杂志审稿人:  
1.  Oral Oncology
2.  Journal of Medical Imaging and Radiation Oncology
3.  Journal of Analytical Oncology
4.  The Hellenic Journal of Nuclear Medicine
5.  Acta Pharmacologica Sinica
6.  实用肿瘤学杂志
7.  The Chinese-German Journal of Clinical Oncology
8.  Plos one
 
发表文章
1.Ze Zheng, Guohui Wang, Li Li, Jeffery Tseng, Fei Sun, Xuequn Chen, Lin Chang, Henry Heng, Kezhong Zhang. Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies.  Enviromental disease. 2016, 1 (1): 24-30
2.Xiaoli Cheng, Wenli Shi, Canguo Zhao,Dan Zhang,Piao Liang,Guohui Wang(co-corresponding author) ,Li Lu. Triptolide sensitizes human breast cancer cells to tumor necrosis factor‑α‑induced apoptosis by inhibiting activation of the nuclear factor‑κB pathway. Mol Med Rep. 2016 Feb 23. doi: 10.3892/mmr.2016.4931. [Epub ahead of print]

    Dong Xu, Renduo Song, Guohui Wang, Prince V.S. Jeyabal, Amanda M. Weiskoff, Kefeng Ding, Zheng-Zheng Shi. Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β- inhibitor 2-PP1 positive feedback loop.  Oncotarget. 2015. Dec. DOI: 10.18632/oncotarget.6496
    Wu H, Wang G(co-first author), Wang Z, An S, Ye P1 Luo S. A negative feedback loop between miR-200b and the NF-κB pathway via IKBKB/IKK-β in breast cancer cells. FEBS J. 2015 Oct 3. doi: 10.1111/febs.13543. [Epub ahead of print]
    Guo CF1, Liu Q, Wang G, Wang Y, Shi Z, Suo Z, Chu CW, Ren Z. Fatigue-free, superstretchable, transparent, and biocompatible metal electrodes. Proc Natl Acad Sci U S A. 2015 Sep 21. pii: 201516873.
    Huarong Chen1,2,*, Renduo Song1,*, Guohui Wang(co-first author)*, Zonghui Ding1 , ChunyingYang3 , Jiawei Zhang2 , Zihua Zeng4, Valentina Rubio1 , Luchang Wang1 , Nancy Zu1 , Amanda M. Weiskoff1 , Laurie J. Minze5 , Prince V.S. Jeyabal1 , Oula C. Mansour1 , Li Bai1 , William C. Merrick6, Shu Zheng2 & Zheng-Zheng Shi. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. Scientific Reports ,2015). doi:10.1038/srep13241
    Deng Z, Li Y, Fan J, Wang G, Li Y, Zhang Y, Cai G, Shen H, Ferrari M, Hu TY.  Circulating Peptidome to Indicate the Tumor-resident Proteolysis. Sci Rep. 2015 Mar 19;5:9327. doi: 10.1038/srep09327
    张伟光, 王国慧(通讯), 张卫东等 ,18氟-氟代脱氧葡萄糖PET/CT显像与传统影像探测乳腺癌治疗后复发与转移的临床价值. 中华医学杂志。 2013, 93(19): 1446-1449.
    张伟光,王国慧(通讯) 张卫东 樊卫 ·FDG PET/CT评估乳腺癌治疗后淋巴结转移的临床价值。中山大学学报(医学科学版) ,2013,2013, 34(1): 135-139.
    Guohui Wang, Gang Liu, Xiaogang Wang, Seema Sethi, Ali-Fehmi, Rouba, Judith Abrams , Ze Zheng, Kezhong Zhang, Stephen Ethier, and Zeng-Quan Yang . ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC cancer. 2012 Jun 8;12(1):225.
    Guohui Wang, Xuebao Zhang , Xiaogang Wang, Zeng-Quan Yang, and Kezhong Zhang. Endoplasmic Reticulum Factor ERLIN2 Regulates Cytosolic Lipid Contents in Cancer Cells.  Biochemical journal. 2012 , Sep 15;446(3):415-25.
    Wang G, Wu Y, Zhang W, Li J, Wu P, Xie C. Clinical value of whole-body F-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with carcinoma of unknown primary. J Med Imaging Radiat Oncol. 2013 Feb;57(1):65-71.
    Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. ER-tethered transcription factor crebh regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress. Hepatology. 2011 Nov 16. doi: 10.1002/hep.24783.
    Stevens JB, Abdallah BY, Liu G, Ye CJ, Horne SD, Wang G, Savasan S, Shekhar M, Krawetz SA, Hüttemann M, Tainsky MA, Wu GS, Xie Y, Zhang K, Heng HH. Diverse system stresses: common mechanisms of chromosome fragmentation. Cell Death Dis. 2011 Jun 30;2:e178. doi: 10.1038/cddis.2011.60.
    Guohui Wang, Zeng-Quan Yang, Kezhong Zhang: Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. Am J Transl Res 2010;2(1):65-74.
    Guohui Wang, Sanjay Rajagopalan, Qinghua Sun, and Kezhong Zhang. Real-world exposure of airborne particulate matter triggers oxidative stress in an animal model. Int J Physiol Pathophysiol Pharmacol 2010;2(1):64-68.
    Suzette Laing, Guohui Wang, Tamara Briazova, Chunbin Zhang, Aixia Wang, Ze Zheng, Alexander Gow, Alex F. Chen, Sanjay Rajagopalan, Lung Chi Chen, Qinghua Sun, and Kezhong Zhang. Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues,  Am J Physiol Cell Physiol, 2010 Oct;299(4):C736-49
    王国慧, 何军芳, 樊卫, 吴沛宏. 重组Ad-Cp-CDglyTK双自杀基因腺病毒载体构建及体外抑制鼻咽癌细胞的实验研究. 中国病理生理杂志. 2008,  24(2): 215-219.
    王国慧,Eddie W. F. Lau , Ramdave Shakher, Peter EU, Val Johnston , Rodney J. Hicks. 177Lu-octreotate治疗神经内分泌胃肠胰腺肿瘤的SPECT显像研究. 中华核医学杂志, 2007, 27(5):313-314.
    王国慧, Eddie W. F. Lau , Ramdave Shakher, David S. Binns ,  Annette Hogg, Elizabeth Drummond , Rodney J. Hicks. 18F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值. 癌症,2007,26(6): 638-642.
    王国慧, Eddie W.F. Lau, Ramdave Shakher, Robert E. Ware,  David S. Binns,  Annette Hogg, Elizabeth Drummond,Rodney J. Hicks. 18 F-FDG PET/CT 发现肿瘤患者意外病灶的临床价值.  中华核医学杂志, 2007, 27(1): 1-4.
    Guohui Wang, Eddie W. F.Lau, Ramdave Shakher,Danny Rischin, Robert E. Ware,Emily Hong,David S. Binns, Annette Hogg, , Elizabeth Drummond, Rodney J. Hicks, How do oncologists deal with incidental abnormalities on whole-body fluorine-18 fluorodeoxyglucose PET/CT? Cancer, 2007, 109(1):117-24.
    梁培炎, 王国慧, 李群, 杨小春, 张伟光, 蔡燕君.  99Tcm-HL91乏氧显像在鼻咽癌治疗中的应用. 中华核医学杂志. 2006,26(2):97-99.
    吴沛宏,王国慧. 肿瘤MR分子影像学研究进展. 国外医学(放射医学核医学分册). 2005 Vol.29 No.3 P.139-142
    王国慧,刘长征,梁昌盛, 樊卫. 188Re-BAC5 对鼻咽癌的免疫导向治疗的实验研究,核技术,2003. 26(5): 375-379
    Wang guohui, Fan  Wei, Zhang Weiguang,et al . Clinical study of sentinel lymph nodes guided by combined isotope-dye technique in patients with lingual carcinoma. Chin Med J. 2003.116(8) :1213-1215
    王国慧,樊卫,张伟光,戴军进, 杨小春, 彭汉伟. 核素显像-染色法探测舌癌前哨淋巴结的临床研究 .中华核医学杂志. 2003. 23(3): 143-144
    王国慧,樊卫. 基因显像在肿瘤治疗中的作用(综述). 肿瘤防治杂志, 2002.5suppl. :436-438.
    樊卫、王国慧, 杨名添 ,张伟光, 戴军进 ,杨小春. 放射性碘131在荷乳腺癌裸鼠的生物分布与核素显像的实验研究,癌症,2004, 23(7): 808-811。
    王国慧,樊卫, 张伟光.  SPECT联合X线诊断鼻咽癌骨转移的临床研究,现代临床医学生物工程学杂志,2003, 9(6): 471-472
    樊卫、王国慧, 刘学奎 , 曾宗渊.  99TcmO4- 洗脱液动态显像在颌下腺移位术中的临床应用研究. 中华核医学杂志. 2005,25(5):301-303。

 
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